Understanding Time-in-Range, its assessment, and targets to aim for

Beyond HbA_1C, It is time to think Time-in-Range

Glycemic variability is a common challenge for people with diabetes and has a range of serious consequences^{1- 9}

It is known today that two people with identical HbA_1c level of 8.0% can have markedly different degrees of glycemic variability^10*

Beyond HbA_1c, rise of Time-in-Range as a new key metric for Glycemic control

Evaluating TIR can aid understanding whether hypoglycemia (time-below-range) or hyperglycemia (time-above-range) are improving with treatment over time^12,13

As per the latest International Consensus on Time-in-Range, TIR is identified as a metric of glycemic control that provides more actionable information than HbA_1C alone¹¹

Optimizing HbA_1c to <7.0%^12,14 and reducing Glycemic variability: TIR>70% and %CV≤36%^6,12,13 helps achieve better patient outcomes^9,13-16

Which Time-in-Range target should you aim for?

International guidelines recommend a target of>70% TIR (70-80 mg/dL) for most adult patients with T1DM or T2DM^11,13†

Optimizing Time-in-Range

A fundamental aspect to effective diabetes management¹¹

*15-day glucose traces of two patients who had identical HbA1c of 8.0% but different degrees of GV. High GV in patient 1 was reflected by numerous episodes of both hypo- and hyper- glycemia, whereas low GV in patient 2 resulted in no such episodes.¹⁰

^†It is recommended that most adult patients spend <1 hour per day with blood glucose <70 mg/dL (<3.9 mmol/L); <15 minutes per day with blood glucose <54 mg/dL (<3.0 mmol/L); <1 hour 12 minutes per day with blood glucose >250 mg/dL (>13.9 mmol/L); and <6 hours per day with blood glucose >180 mg/dL (>10.0 mmol/L), although CGM-based targets vary for different diabetes populations. For people with T1DM aged <25 years, if the HbA_1c goal is 7.5%, then the TIR target should be set to approximately 60%. For older patients or those at high risk, the TIR target is 50% although individualized decision making is recommended. There is insufficient data to allow recommendation of TIR target for pregnant women.^11,13

# Includes percentage of values <54 mg/dL (3.0 mmol/L).¹¹

**Includes percentage of values >250 mg/dL (13.9 mmol/L).¹¹

Abbreviations

HbA_1c, Hemoglobin A_1c; TIR, Time-in-Range; CV, Coefficient of Variation; T1DM, Type 1 Diabetes Mellitus; T2DM, Type 2 Diabetes Mellitus; GV, Glycemic variability.

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