You can imagine more than 90% of CRSwNP patients losses their ability's of smell

Smell is mediated by Olfactory Sensory Neurons in the olfactory epithelium. Horizontal Basal Stem Cells regenerate these Olfactory Sensory Neurons, maintaining the sense of smell.

References

Yan X, Whitecroft LK, Hummel T. Olfaction: Sensitive indicator of inflammatory burden in chronic rhinosinusitis.Laryngoscope Investig Otolaryngol. 2020;28;5(6):992-1002. doi:10.1002/lio2.485
Chen M, Reed RR, Lane AP. Chronic inflammation directs an olfactory stem cell functional switch from neuroregeneration to immune defense. Cell Stem Cell. 2019;25(4):501-513.doi:10.1016/j.stem.2019.08.011
Rouyar A, Classe M, Gorski R, et al. Type 2/Th2-driven inflammation impairs olfactory sensory neurogenesis in mouse chronic rhinosinusitis model. Allergy. 2019;74(3):549-559. doi:10.1111/all.13559
Mullol J, Mariño-Sánchez F, Valls M, et al. The sense of smell in chronic rhinosinusitis. J Allergy Clin Immunol. 2020;145(3):773-776. doi:10.1016/j.jaci.2020.01.024
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