Multiple Myeloma: Renal Impairment
Renal impairment is a common complication in patients with multiple myeloma
Patients with renal impairment are o en excluded from or underrepresented in clinical trials1
...and it forms a core part of the CRAB criteria used to diagnose multiple myeloma2,3
Renal impairment adversely affects survival
The median survival of patients with renal impairment is approximately half that of patients without renal impairment4
There are multiple contributors to renal impairment2
Depth of renal impairment at diagnosis is predictive of poor prognosis6
eGFR (mL/min/1.73m²)
References
- Richardson PG, et al. Blood Cancer J. 2018; 8(11)109;
- Faiman B et al. Clin J Oncol Nurs 2017;21(5 Suppl):19–36;
- Rajkumar SV, et al. Lancet Oncol. 2014;15:e538–48;
- Eleutherakis-Papaiakovou V, et al. Leuk Lymphoma 2007;48:337-41;
- Dimopoulos AM, et al. Leukemia. 2008;22:1485–93;
- Uttervall K et al. PLoS One. 2014;9;e101819
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MAT-AE-2300647-V1-Nov-23