All Infant Protection

RSV is a leading cause of hospitalization in all infants

All infants need protection from RSV

Most Hospitalizations for RSV occur in Healthy Full Term Infants^1-3

Respiratory Syncytial Virus–Associated Hospitalizations Among Children Less Than 24 Months of Age | Pediatrics | American Academy of Pediatrics (aap.org)

aEstimate includes previously healthy premature subjects <37 weeks’ gestation, and less than 2 years old.

References

Hall CB, et al. Pediatrics. 2013;132(2):e341-e348.
Arriola CS, et al. J Pediatric Infect Dis Soc. 2020;9(5):587-595 Supplemental Tables 4-6.
Rha B, et al. Pediatrics. 2020;146(1):e20193611.

RSV Infant ICU Admissions and Mechanical Ventilation in the US¹

Surveillance through the Influenza Hospitalization Surveillance Network from October 2014-April 2015

Infant RSV ICU Admissions (n=336)

26% (221/851) of hospitalized healthy term infants were admitted to ICU¹

Infant RSV Requiring Mechanical Ventilation (n=82)

22% (49/221) of ICU admitted healthy term infants required mechanical ventilation¹

CMC: chronic medical condition (includes chronic lung disease, cardiovascular disease, upper airway abnormality, asthma, neurologic/neuromuscular conditions, blood disease, renal disorder, immunocompromised, chronic metabolic disease, liver disease, and other); ICU: Intensive Care Unit; Preterm: born at <37 weeks gestational age; Term: born at 37+ weeks gestational age. Data from the US, % of Infant RSV ICU admissions may vary in other countries.

Estimated Burden of Community-Onset Respiratory Syncytial Virus–Associated Hospitalizations Among Children Aged <2 Years in the United States, 2014–15 - PMC (nih.gov)

"There is an urgent and universal need to develop products to reduce child mortality andmorbidity through prevention of RSV disease"

Ruth A. Karron,
MD Center for Immunization ResearchDepartment of International HealthJohns Hopkins Bloomberg School of Public HealthBaltimore, MD, USA Science. May 14, 2021:Vol. 372, Issue 6543, pp 686-687.

"Because most children hospitalized with RSV have no underlying medical condition or history of prematurity, interventions against RSV used to broadly target all young infants are likely to result in the greatest impact. "

Brian Rha, MD MSPH
Division of Viral DiseasesCenters for Disease Control and PreventionAtlanta, GA, USA Pediatrics. July 2020: Vol. 146, Issue 1, p. e20193611.

Reference