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All Infant Protection



RSV is a leading cause of hospitalization in all infants



All infants need protection from RSV

Most Hospitalizations for RSV occur in Healthy Full Term Infants1-3

Respiratory Syncytial Virus–Associated Hospitalizations Among Children Less Than 24 Months of Age | Pediatrics | American Academy of Pediatrics (aap.org)

aEstimate includes previously healthy premature subjects <37 weeks’ gestation, and less than 2 years old.

References

  1. Hall CB, et al. Pediatrics. 2013;132(2):e341-e348.
  2. Arriola CS, et al. J Pediatric Infect Dis Soc. 2020;9(5):587-595 Supplemental Tables 4-6.
  3. Rha B, et al. Pediatrics. 2020;146(1):e20193611.

RSV Infant ICU Admissions and Mechanical Ventilation in the US1

Surveillance through the Influenza Hospitalization Surveillance Network from October 2014-April 2015

Infant RSV ICU Admissions (n=336)

  • 26% (221/851) of hospitalized healthy term infants were admitted to ICU1

Infant RSV Requiring Mechanical Ventilation (n=82)

  • 22% (49/221) of ICU admitted healthy term infants required mechanical ventilation1

 

CMC: chronic medical condition (includes chronic lung disease, cardiovascular disease, upper airway abnormality, asthma, neurologic/neuromuscular conditions, blood disease, renal disorder, immunocompromised, chronic metabolic disease, liver disease, and other); ICU: Intensive Care Unit; Preterm: born at <37 weeks gestational age; Term: born at 37+ weeks gestational age. Data from the US, % of Infant RSV ICU admissions may vary in other countries.

Estimated Burden of Community-Onset Respiratory Syncytial Virus–Associated Hospitalizations Among Children Aged <2 Years in the United States, 2014–15 - PMC (nih.gov)

"There is an urgent and universal need to develop products to reduce child mortality and morbidity through prevention of RSV disease"

Ruth A. Karron,
MD Center for Immunization Research Department of International Health Johns Hopkins Bloomberg School of Public Health Baltimore, MD, USA Science. May 14, 2021:Vol. 372, Issue 6543, pp 686-687.

"Because most children hospitalized with RSV have no underlying medical condition or history of prematurity, interventions against RSV used to broadly target all young infants are likely to result in the greatest impact. "

Brian Rha, MD MSPH
Division of Viral Diseases Centers for Disease Control and Prevention Atlanta, GA, USA Pediatrics. July 2020: Vol. 146, Issue 1, p. e20193611.

Reference

  1. Arriola CS, et al. J Ped Inf Dis Soc. 2019; 9(5): 587-595. Supplemental Tables 4-6.
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MAT-BH-2300308-V1- May 2023