Burden of Disease
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RSV Is a Common Respiratory Virus With Symptoms Varying by Age-Group
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Abbreviations
COPD, chronic obstructive pulmonary disease; LRTIs, lower respiratory tract infections; mos, months; yrs, years.
References
- Adapted from: Openshaw PJM, et al. Annu Rev Immunol. 2017;35:501-532.
- Carvajal JJ, et al. Front Immunol. 2019;10:2152.
- Falsey AR,et al. N Engl J Med. 2005;352(17):1749-1759.
RSV Causes Substantial Disease Burden for Newborns and Infants Globally
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Reference
- Li Y, et al. Lancet. 2022 May 19:S0140-6736(22)00478-0. doi: 10.1016/S0140-6736(22)00478-0.
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RSV is a Leading Cause of LRTIs Among Infants Worldwide1,2
Estimated Percentage of acute LRTI attributable to RSV infection
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a Only includes hospitalizations due to bronchiolitis; bRSV was a cause of 28% of all hospitalization cases in infants in France.
References
- Nair H, et al. Lancet. 2010;375(9725):1545-55.
- Shi T, et al. Lancet. 2017;390(10098):946-958.
- Rha B, et al. Pediatrics. 2020;146(1):e20193611.
- Reeves RM, et al. Influenza Other Respir Viruses. 2017;11(2):122-129.
- El-Hajje MJ, et al. Eur J Pediatr. 2008;167(4):435-436.
- Weigl J, et al. Eur J Clin Microbiol Infect Dis. 2001;20(7):452-9.
- Sanchez-Luna M, et al. Curr Med Res Opin. 2016;32(4):693-698.
- Cangiano G, et al. Pediatr Pulmonol. 2016;51(12):1330-1335.
- Zhang Y, et al. J Global Health. 2015;5(2):020417.
- Inagaki A, et al. Jpn J Infect Dis. 2021;74(1):23-28.
- Ahmed, A., et al. (2018). "An overview of respiratory syncytial virus infections in Saudi Arabia." The Journal of Infection in Developing Countries 12(11): 929-936
- Alkharsah, K. R. (2022). "The Scope of Respiratory Syncytial Virus Infection in a Tertiary Hospital in the Eastern Province of Saudi Arabia and the Change in Seasonal Pattern during and after the COVID-19 Pandemic." Medicina 58(11): 1623.
Abbreviation
LRTI, lower respiratory tract infection. Data are derived from different studies and over different years.
Prevalence in RSV hospitalized with bronchiolitis during seasonal epidemics
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aCoronavirus type OC43, 229E, NL63, and HKU1. Age range of children not specified.
References
- Meissner HC. N Engl J Med. 2016;374(1):62-72.
- Al Aql, F., et al. (2016). "Guidelines for palivizumab prophylaxis in infants and young children at increased risk for respiratory syncytial virus infection in Saudi Arabia.
" International Journal of Pediatrics and Adolescent Medicine 3(1): 38-42. - Elham E, B. and E. Malak M (2013).
"Viral agents causing acute lower respiratory tract infections in hospitalized children at a tertiary care center in Saudi Arabia."
RSV Average Hospitalization days
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5.9 days in hospital
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6.5 days in hospital
total of 754 beds (502 inpatient beds, 56 emergency beds, 77 ICU beds, 32 psychiatry beds, and 87 special auxiliary beds).
AComorbidities assessed: congenital cardiopathies, 2.3%; congenital defects with cardiac affectation, 0.7%; prematurity, 0.3%; bronchopulmonary dysplasia, 1%.
References
- Gil-Prieto R, et al. Medicine (Baltimore). 2015;94(21):e831.,
- Alkharsah, K. R. (2022).
"The Scope of Respiratory Syncytial Virus Infection in a Tertiary Hospital in the Eastern Province of Saudi Arabia and the Change in Seasonal Pattern during and after the COVID-19 Pandemic." Medicina 58(11): 1623.
RSV Causes Substantial Hospitalization Among All Infants and Young Children In Spain
Epidemiologic survey in Spain estimating the burden of RSV in all children <5 years of age during a 15-year period (1997–2011)1
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326,175 hospital discharges
Due to bronchiolitis in children <5 years of age
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5.9 days in hospital
on average in children ≤2 years of age
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4,136/100,000 incidence of hospitalization during 1st yearof life
highest incidence among all age ranges
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446 deaths
355 (80%)<12 months of age 335 (75%) without comorbidities*
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96.8 % of children were otherwise healthy
Only 3.2% of children <5 years of age presented with ≥1 comorbidity*
AComorbidities assessed: congenital cardiopathies, 2.3%; congenital defects with cardiac affectation, 0.7%; prematurity, 0.3%; bronchopulmonary dysplasia, 1%.
Reference
- Gil-Prieto R, et al. Medicine (Baltimore). 2015;94(21):e831.