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Prurigo Nodularis

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Science in Prurigo Nodularis

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PN Expert Interview Series with Dr. Shawn Kwatra

PN Expert Interview Series with Dr. Shawn Kwatra

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Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials

Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials

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There is significant unmet need in the management of PN¹

There is significant unmet need in the management of PN¹

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Mechanism of Prurigo Nodularis Disease

Mechanism of Prurigo Nodularis Disease

In this comprehensive exploration, we delve into the intricate pathophysiology of Prurigo Nodularis (PN), highlighting the pivotal roles of neuronal sensitization, inflammation, and pruritus. This challenging dermatological condition is characterized by dermatological condition histopathologic alterations, including enhanced hypervascularization, epidermal hyperkeratosis, and dermal fibrosis. Explore the connection between PN and the proinflammatory Th2 cytokine IL-13, shedding light on its binding to IL-4R across various skin components.

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Prurigo Nodularis is a distinct, Chronic, Neural and Immune- Mediated skin disease characterized by intense itch and Nodular Lesions¹

Prurigo Nodularis is a distinct, Chronic, Neural and Immune- Mediated skin disease characterized by intense itch and Nodular Lesions¹

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Type 2 Inflammation may play a role in Prurigo Nodularis Pathophysiology1

Type 2 Inflammation may play a role in Prurigo Nodularis Pathophysiology1

Exact pathophysiology of PN is currently not understood. Based on the evolving literature, type 2 inflammation may play a role in PN.

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